Overview
SS-31 (elamipretide) binds cardiolipin on the inner mitochondrial membrane to improve energy production efficiency. It’s one of the most-studied mitochondrial peptides in clinical research.
Preparation
Reconstitute a 10 mg vial with 1 mL of bacteriostatic water (BAC) for a 10 mg/mL concentration. The concentrated dilution keeps full doses in a single insulin syringe.
| Vial | BAC | Concentration |
|---|---|---|
| 10 mg | 1 mL | 10 mg/mL |
Protocol
| Period | Dose | Units (@ 10 mg/mL) | Frequency |
|---|---|---|---|
| Weeks 1–2 | 5 mg (5,000 mcg) | 50 units (0.50 mL) | 1x/day |
| Weeks 3–8 | 10 mg (10,000 mcg) | 100 units (1.00 mL) | 1x/day |
Cycle
8–12 week cycles. Start at 5 mg for the first two weeks, then hold at 10 mg — the dose used in most clinical protocols. Advanced runs go to 15–20 mg split across two injections.